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< 先ほど無事帰還しました！ | メイン | 老人病院の当直依頼！！ >
2010.04.26 08:18 |  診療  |  研究  |  仕事 / 職場  |  生活 / くらし  |  趣味  |  旅行 / 宿  |  タッカ―  | 推薦数 : 0

要旨アマリール発売１０周年記念講演会！

　東京で開催されてアマリール１０周年記念講演会では第三世代のＳＵ剤であるグリメピリド（アマリール）の有効性と安全性が強調され、従来は低血糖危惧からＤＭ（中程度～重症）が主たる治療対象群であったが、今回は０．５ｍｇも発売となったことから、軽症例（あるいはＩＧＴ）も含めた対象拡大が期待されるとしている。演者の加来教授によると攻めのＳＵ剤となり得るとしている。最近発表された大規模試験結果からも大血管疾患も含めたリスク低減効果がはっきり認められたのはＳＵ剤であり、他のチアゾリジン誘導体やＤＰＰⅣ阻害剤では副作用の点で重大な問題があるのでは？と慎重な評価になっているのが現状であるとしている。特にチアゾリジン系剤では有意な心不全と骨折合併が問題となっており、海外ではＤＭ治療のアルゴリズムとしてＦｉｒｓｔ選択としては認められないとされており、ＢＧ剤とＳＵ剤がＦｉｒｓｔ権をガッチリ握っている現状である。したがって、ＳＵ剤の第一主導は変わることなくこれからも継続するであろうとの結論であった。最後に元横綱千代の富士の九重親方が特別出演して、相撲界と糖尿病について座談会があったが、とても楽しく拝聴いたしました！結構充実した素晴らしい講演会であったと思います！！

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