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< トリインフルエンザ | メイン | 前立腺がんとは？ >

今度は抗がん剤です！

ryu-chan / 2008.10.09 15:55 / 推薦数 : 0

新しいプレスを出させていただきました。

今度は、抗ガン剤です。

アンジェスの子会社であるジェノミディアの開発していたHVJエンベロープベクター（HVJ-E）が、抗がん剤となることが分かりました。

HVJ-Eは、がん免疫に重要な樹状細胞に作用して、がんを攻撃するTリンパ細胞やナチュラルキラー（NK）細胞を活性化することが明らかとなりました。

また、同時にがん免疫を抑えてしまうといわれている制御性Tリンパ細胞の機能をコントロールすることで、効率的にがん免疫を活性化することが明らかとなっています。

ということで、あれ？がんに効くのでは、ないか？と阪大の金田先生のラボとジェノｍディアの研究で抗がん剤の可能性を調べました。

すると、いくつかのがん動物モデルで効果が出ました。

特に、ホルモン抵抗性の前立腺がんモデルで良い結果を出すことができました。

そこで、がんの開発に得意なＴＳＤという会社で前立腺がんの抗ガン剤としての独占的製造開発販売権を供与することになりました。

ＴＳＤは、元々アストラゼネカや武田にいたガンの開発などをしていた方々が作った会社で期待できるので、今回開発をお任せすることにしました。

前立腺がんの国内での年間新規罹患患者数は、2005年には3万7060人から、2010年に5万3357人、2020年に7万8468人になると推測されており、今後高齢化に伴って急速に増加すると予測されています（がん・統計白書　2004）。

また、国内の死亡者数は、2005年で9,265人であり（国立がんセンター、がん情報サービス）、有効性が高い新たな治療薬の開発が切望されている疾患領域です。

有名なところでは、天皇陛下も前立腺ガンですね。ホルモン剤が一般的な治療法ですが、最後は利かなくなります。末期の治療方法はないので、ＨＶＪ－Ｅは期待されます。

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