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ryu-chan
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前立腺がんとは? >
今度は抗がん剤です!
ryu-chan
/ 2008.10.09 15:55 / 推薦数 : 0
新しいプレスを出させていただきました。
今度は、抗ガン剤です。
アンジェスの子会社であるジェノミディアの開発していた
HVJ
エンベロープベクター(
HVJ-E
)が、抗がん剤となることが分かりました。
HVJ-E
は、がん免疫に重要な樹状細胞に作用して、がんを攻撃する
T
リンパ細胞やナチュラルキラー(
NK
)細胞を活性化することが明らかとなりました。
また、同時にがん免疫を抑えてしまうといわれている制御性
T
リンパ細胞の機能をコントロールすることで、効率的にがん免疫を活性化す
ることが明らかとなっています。
ということで、あれ?がんに効くのでは、ないか?と阪大の金田先生のラボとジェノmディアの研究で抗がん剤の可能性を調べました。
すると、いくつかのがん動物モデルで効果が出ました。
特に、ホルモン抵抗性の前立腺がんモデルで良い結果を出すことができました。
そこで、がんの開発に得意なTSDという会社で前立腺がんの抗ガン剤としての独占的製造開発販売権を供与することになりました。
TSDは、元々アストラゼネカや武田にいたガンの開発などをしていた方々が作った会社で期待できるので、今回開発をお任せすることにしました。
前立腺がんの国内での年間新規罹患患者数は、
2005
年には
3
万
7060
人から、
2010
年に
5
万
3357
人、
2020
年に
7
万
8468
人になると推測されており、今後高齢化に伴って急速に増加すると予測されています(がん・統計白書
2004
)。
また、国内の死亡者数は、
2005
年で
9,265
人であり(国立がんセンター、がん情報サービス)、有効性が高い新たな治療薬の開発が切望されている疾患領域です。
有名なところでは、天皇陛下も前立腺ガンですね。ホルモン剤が一般的な治療法ですが、最後は利かなくなります。末期の治療方法はないので、HVJ-Eは期待されます。
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