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Wegener症候群において視神経症optic neuropathyを生じる機転
Arthritis Care Res 61(8),1133-1139,2009
（１）眼窩内腫瘤による視神経圧迫 （compression of the optic nerve from an inflammatory mass within the orbit）
（２）視神経自体の肉芽腫性炎症（granulomatous inflammation of the optic nerve itself）
（３）後毛様体動脈の血管障害による前部虚血性視神経症anterior ischemic optic neuropathy from vascular compromise of the posterior ciliary artery. The last mechanism is analogous to the most common pathway through which patients with giant cell arteritis lose vision.
memo orbital apex syndrome（眼窩尖端部症候群）
鑑別診断
ーInflammatory
・Wegener's granulomatosis
・Giant cell arteritis
・Churg-Strauss syndrome
・Sarcoidosis
ーInfectious
・Fungi
・Bacteria
・Viral
ーNeoplastic
ーCavernous sinus thrombosis（海綿静脈洞血栓症）
Deep, aching orbital pain, diplopia, conjunctival injection, proptosis, loss of vision, ocular motor dysfunction, or combinations of these features.
Severe orbital apex syndromes: Full ptosis, a dilated pupil, and a numb eye that does not move in any direction.
Owing to the Lesion located at the apex of the orbit adjacent to the carotid artery and cavernous sinus, the region through which cranial nerves II, III, IV, VI, and V1 course
Arthritis Care & Research
Volume 61, Issue 8, Pages 1133-1139
