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Stefansson H et al. Large recurrent microdeletions associated with schizophrenia. Nature. 2008 Jul 30. [Epub ahead of print]
Gene-Hunters Find Hope and Hurdles in Schizophrenia Studies
By NICHOLAS WADE (NY TIMES)
that the genetic component of the disease is due to a large number of variants, each of which is very rare, rather than to a handful of common variants.
“What is beginning to emerge is that a lot of the risk of brain diseases is conferred by rare deletions,” Dr. Stefansson said. The three variants discovered by his group and Dr. Sklar’s involve the deletion of large sections of DNA from specific sites in a patient’s genome.
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