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BSR and BHPR guidelines for the management of adults with ANCA associated vasculitis.
Rheumatology (Oxford). 2007 Oct;46(10):1615-6
Treatment of antineutrophil cytoplasmic antibody associated vasculitis: a systematic review.
JAMA. 2007 Aug 8;298(6):655-69
Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis.
J Am Soc Nephrol. 2007 Jul;18(7):2180-8
(The investigators were permitted to use their local procedure with respect to (1) plasma filtration or centrifugation, (2) vascular access, (3) anticoagulation, and (4) daily or alternate-day exchanges. The following aspects of the procedure were mandated in the protocol: (1) A total of seven plasma exchanges within 14 d of study entry, (2) a plasma exchange volume of 60 ml/kg on each occasion, and (3) volume replacement with 5% albumin. The use of fresh frozen plasma at the end of the procedure to replenish coagulation factors was recommended but not mandated for patients who were at risk for hemorrhage, for example after kidney biopsy.)
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