リウマチ

◎　Seo P: Pregnancy and vasculitis. Rheum Dis Clin North Am. 2007 May;33(2):299-317（The Johns Hopkins University）.

・J Gynecol Obstet Biol Reprod (Paris). 1995;24(7):747-50.Links
[Association of Takayasu's arteritis, pregnancy and Still's disease]

　◎　妊娠中に発症したAOSDの2例（20週・22週：ともに除外診断後ステロイド治療）Pan VL, Haruyama AZ, Guberman C, Kitridou RC, Wing DA. Newly diagnosed adult-onset Still disease in pregnancy. Obstet Gynecol. 2003 May;101(5 Pt 2):1112-6（米国）
　◎　PREGNANCY AND RHEUMATOID ARTHRITIS. Rheumatic Diseases Clinics of North America - Volume 23, Issue 1 (February 1997)
　この1997年のレビューはRA合併妊娠に関するものであるが、AOSDについても触れている。To conclude, in all 21 pregnancies reported, no consistent pattern of the interaction between pregnancy and Still's disease emerged. Acute flares can occur during and after pregnancy, requiring high doses of salicylates or prednisone. RAのように妊娠中に軽快するという傾向はなさそうである。
　◎　 E. Liozon, K. Ly, Y. Aubard 1 and E. Vidal. Intravenous immunoglobulins for adult Still's disease and pregnancy. Rheumatology 1999; 38: 1024-1025（フランス）
　この1999年の報告（レター）時点で、著者等は成人スチル病に合併した33妊娠（24症例）の文献報告を引用している。AOSDの治療の主流はグルココルチコイドであり、妊娠合併AOSDにも有効で比較的安全に使えると記載している。彼らの症例はhepatic toxicity of salicylates・excessive weight gain early in pregnancy（a high risk of developing diabetes gestationis）からIVIGが選択された。

その他
・Polyserositis in adult Still's disease with onset during pregnancy(一例報告） Clin Rheumatol. 1994 Sep;13(3):513-7.
・Gerald H. Stein, Bernard Cantor, Richard S. Panush, MD: Adult still's disease associated with pregnancy. Arthritis & Rheumatism Volume 23, Issue 2 , Pages 248 - 250、1980
・Adult-onset Still's disease: A case with onset during pregnancy(一例報告） Arthritis & Rheumatism Volume 28, Issue 8 , Pages 957 - 957,1985

その他
(1) Mok MY, Lo Y, Leung PY, Lau CS（香港）：Pregnancy outcome in patients with adult onset Still's disease. J Rheumatol. 2004 Nov;31(11):2307-9.
Pregnancy outcome of patients with adult onset Still's disease (AOSD) has not been addressed. We report the maternal and fetal morbidity of 5 pregnancies from 3 Chinese patients with AOSD and review another 17 pregnancies from 14 patients reported in the English literature. Nine patients had their first manifestation in the 5th to 6th gestational month. Disease relapse in patients with known AOSDoccurred most commonly in the post-partum period. Most did not respond satisfactorily to nonsteroidal antiinflammatory agents alone, but responded to administration of corticosteroids, especially in high doses.

(2) Le Loët X, Daragon A, Duval C, Thomine E, Lauret P, Humbert G.（フランス）: Adult onset Still's disease and pregnancy. J Rheumatol. 1993 Jul;20(7):1158-61.
The interactions between pregnancy and adult onset Still's disease (AOSD) are unclear. Between 1983 and 1990, 5 pregnancies occurred in 4 women with AOSD. AOSD occurred at the 5th and 6th month of the 1st pregnancy in 2 patients; a 2nd pregnancy occurring in one of them was not associated with a flare. In the other 2 patients pregnancy occurred 36 and 44 months after the AOSD; during gestation only transient arthralgia were observed in both cases. Pregnancy seems to have no effect on AOSD, and conversely, in our experience, AOSD has no influence on pregnancy, fetal growth or infant health.

(3) 成人スチル病合併妊娠の1症例 日本産科婦人科學會雜誌 Vol.48, No.6(19960601) pp. 431-434