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< SSP:痛足動足症？？？ | メイン | 科学と科学的知識の利用に関する世界宣言 >
2009.09.27 19:00 |  診療  |  医療事故  |  その他（一般）  |  その他（医療関連）  |  ミチバ  | 推薦数 : 4

注意：オメプラゾールのジェネリック→プロポフォール

・最新のＮＥＪＭのCORRESPONDENCEに以下のような記事がありました。

Hypersensitivity to Generic Drugs with Soybean Oil 

 vol.361:1317-1318, Sep 24, 2009, No. 13

http://content.nejm.org/cgi/content/full/361/13/1317

 

オメプラゾール（日本の先発薬品の商品名は、オメプラール）のジェネリックのカプセル製剤でアナフィラキシーを起こした２症例の紹介です。先発品では、そういうアレルギーがなかったのに、ジェネリックに変更して、ショックを起こしたそうです。原因は、カプセルに含まれている大豆油だったそうです。食物アレルギーのある人には要注意。

・この論文の引用文献として、プロポフォールでショックというのがありました↓

Hofer KN, McCarthy MW, Buck ML, Hendrick AE. Possible anaphylaxis after propofol in a child with food allergy. Ann Pharmacother 2003;37:398-401. 

 http://www.theannals.com/cgi/content/abstract/37/3/398?ijkey=fe9cbc4297ca4de2ead592faaf646e13759e63ec&keytype2=tf_ipsecsha

 

 

プロポフォールの添付文書↓ 

http://www.info.pmda.go.jp/go/pack/1119402A1073_1_02/

この添付文書には、直接大豆アレルギーのことは書いていませんね。書いた方がよいのでは？

・私は、ジェネリックの使用は否定するものではないのですが、こういう例があるので、要注意ですね。

参考：「ジェネリックデーターベース」というwebsiteがありました。↓

http://db.generic.ochis-net.jp/generic/

 

以下日記

本日朝は地域の草刈り。８時から９時まで草刈り機を使用しました。法事があったので、カミさんとバトンタッチして、シャワー浴びて、礼服着て、法事へ。なかなか礼服似合ってるぞ。最近中年の魅力が出てきたなと自賛。久々にお経を聞いて、昼から会食。結構ビール飲みました。１４時ころ帰宅し、昼寝。１７時前に目が覚めて、眠気覚ましにＰＣでwebsiteやe-mailチェック。そして、このブログを書いてます。これから、机の上の片づけをするつもり。あすは、ブルーマンデー。

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