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| Agent Name | Cadmium and compounds |
|---|---|
| CAS Number | 7440-43-9, varies |
| Formula | Cd, varies |
| Major Category | Metals |
| Synonyms | Cadmium metal; Cadmium compounds: Cadmium sulfide, Cadmium selenide, Cadmium stearate, Cadmium oxide, Cadmium carbonate, Cadmium sulfate, Cadmium chloride; |
| Category | Metals, Elemental |
| Description | Metal: Silver-white, blue-tinged lustrous, odorless solid; |
| Sources/Uses | Sources of cadmium exposure include: emissions from fossil fuel burning (>40 ng/m3 in polluted urban areas); cigarettes (1-3 ug/pack); drinking water (usually <1 ppb); and food (2-40 ppb); [ATSDR ToxProfiles] MINING, SMELTING, OR METALLURGY: Smelt & refine zinc, lead or copper ores; alloy production; reclaim scrap metal; MANUFACTURING: Nickel-cadmium batteries; pigments for plastics, glass, ceramics & paints; printing & dyeing textiles; fungicides; USING OR DISPOSING: Weld, cut, or burn; braze using cadmium-based solder; spray paint; electroplate; remove coatings; |
| Comments | Inhaling high concentrations of cadmium fume can cause acute pneumonitis. At levels common in factories in the past, cadmium accumulated in the kidneys of workers and caused chronic renal injury with elevated urine cadmium and protein levels. Cadmium levels in adult nonsmokers, not occupationally exposed are <0.5 ug/100 ml whole blood and <2 ug/g creatinine in urine. [Zenz, p. 482] In animal studies, high doses increase fetal loss and birth defects. [ATSDR Case Studies #29] |
| Restricted | OSHA standard 1910.1027 defines exposure monitoring, respiratory protection and medical surveillance for workers exposed above the action level of 2.5 ug/m3. |
| Reference Link | OSHA Technical Links: Cadmium |
| Exposure Assessment | |
| BEI | Cd in urine = 5 ug/g creatinine; Cd in blood = 5 ug/L; sampling time not critical; "Monitoring in blood should be preferred during the initial year of exposure and whenever changes in the degree of exposure are suspected." [ACGIH] |
| Skin Designation (ACGIH) | No |
| Bioaccumulates | Yes |
| TLV (ACGIH) | 0.01 mg/m3, as Cd, 0.002 mg/m3, as Cd(respirable fraction) |
| PEL (OSHA) | 0.005 mg/m3, as Cd, see 29 CFR 1910.1027 |
| IDLH (NIOSH) | 9 mg/m3, as Cd |
| Excerpts from Documentation for IDLHs | Human data: It has been reported that exposure to 9 mg/m3 of cadmium fume for 5 hours is a lethal dose [Beton et al. 1966]. Fatalities have resulted from exposures to concentrations estimated to be 40 to 50 mg/m3 for 1 hour [Barrett and Card 1947; Bulmer et al. 1938; Reinl 1961]. The lethal dose of thermally generated cadmium oxide fume of not more than 2,900 mgmin/m3 has been reported [Barrett and Card 1947], which is equivalent to about 85 mg Cd/m3 for 30 minutes. It has been reported that 39 mg Cd/m3 was a fatal exposure after 20 minutes [Zavon and Meadows 1970]. |
| Lethal Concentration | LC50 (rats) = 25 mg/m3/30 min |
| Explanatory Notes | Melting Point = 610° F; Boiling Point = 1409° F; |
| Half Life | Blood: 1-3 months; whole body: 10-100 years; [TDR, p. 233] whole body half-life exceeds 15 years; [Zenz, p. 482] |
| Reference Link | ATSDR - ToxFAQs - Cadmium |
| Adverse Effects | |
| Toxic Pneumonitis | Yes |
| Lung Cancer | Yes |
| Nephrotoxin | Yes |
| Reproductive Toxin | Yes |
| IARC Carcinogen | Known Carcinogen |
| Links to Other NLM Databases | |
| Health Studies | Human Health Effects from Hazardous Substances Data Bank: CADMIUM COMPOUNDS CADMIUM, ELEMENTAL |
| Toxicity Information | Search TOXNET |
| Chemical Information | Search ChemIDplus |
| Biomedical References | Search PubMed |
| Related Information in Haz-Map | |
| Diseases | Diseases associated with exposure to this agent: |
| Processes | Industrial Processes with risk of exposure:
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| Activities | Activities with risk of exposure: |
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